Volume 4, Number 2, June 2007

The ApoAI-CIII-AIV gene cluster and its relation to lipid levels in type 2 diabetes mellitus and coronary heart disease: determination of a novel susceptible haplotype
Puneetpal Singh, Monica Singh, Sunil Gaur, Taranpal Kaur

The present study investigated genetic variation in the 3’ flanking region of ApoA-I (PstI), the 3’ untranslated region of ApoC-III (SstI) and intron 2 of ApoA-IV (XbaI) in 435 type 2 diabetes mellitus patients, divided according to the presence or absence of coronary heart disease (CHD). Uncommon allele frequencies (P2, S2, X2) were 17.5%, 32.5%, 16.2% and 29.5%, 17.9%, 13.8% in patients with and without CHD, respectively. Linkage disequilibrium (D’ = 0.31–0.73, p<0.01) was observed in all diallelic pairs except XbaI/PstI and XbaI/SstI in patients having CHD. Haplotype analysis revealed that P1-S2-X1 is a susceptibility haplotype that increases the risk of CHD in diabetes (OR 2.85, CI 1.51–5.61), exacerbating risk (OR 3.57, CI 1.81–7.45) even after adjustment for confounders.
The findings in the present study suggest that each unit of P1-S2-X1 in diabetes increases the risk of CHD by a factor of 1.37+0.307 (ß + SE), which is manifest in its multiplicative mode.

Diabetes Vasc Dis Res 2007;4:124-129.

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